RESEARCH: CANCER
FOLDING PROJECT #14969 PROFILE

This project looks at how two proteins, Class F Receptors and Patched, control cell growth. When these proteins go haywire, they can cause cancers like Basal Cell Carcinoma and Medulloblastoma. By creating computer models, researchers hope to figure out how these proteins work so they can better understand and treat these diseases.

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

A class of cell surface receptors involved in signal transduction.

Class F receptors are proteins found on the surface of cells. They receive signals from other molecules and transmit them inside the cell, influencing various cellular processes like growth and differentiation. These receptors play a crucial role in normal development but can be implicated in diseases when their activity is disrupted.

Patched Membrane Protein

A transmembrane protein that acts as a negative regulator of the Hedgehog signaling pathway.

Patched is a protein embedded in the cell membrane. It acts like a brake on the Hedgehog signaling pathway, which controls cell growth and development. When Patched is inactive, the pathway becomes overactive, leading to potential problems like cancer.

Basal Cell Carcinoma

A type of skin cancer that arises from the basal cells.

Basal cell carcinoma is a common form of skin cancer that originates in the basal layer of the epidermis. It often presents as a pearly or waxy bump and can grow slowly. Early detection and treatment are crucial to prevent spread.

Medulloblastoma

A type of malignant brain tumor that arises from the cerebellum.

Medulloblastoma is an aggressive brain tumor that typically affects children. It originates in the cerebellum, a region responsible for balance and coordination. Treatment often involves surgery, chemotherapy, and radiation therapy.