RESEARCH: CANCER
FOLDING PROJECT #14946 PROFILE

This project looks at how Class F Receptors and Patched proteins control how cells develop. When these proteins don't work right, they can cause cancer like Basal Cell Carcinoma and Medulloblastoma. By studying how these proteins activate, we hope to learn more about why these cancers happen.

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

Receptors that play a role in cell signaling and differentiation.

Class F receptors are a type of protein found on the surface of cells. They receive signals from other molecules and trigger changes inside the cell, affecting processes like growth and development. Disruptions in their function can contribute to diseases like cancer.

Patched

A protein that regulates the activity of other proteins involved in cell growth and differentiation.

Patched is a protein that acts as a brake on cellular signaling. It helps control the activity of other proteins involved in processes like cell growth and division. When Patched is not functioning properly, it can lead to uncontrolled cell proliferation, contributing to diseases like cancer.

Basal Cell Carcinoma

A type of skin cancer that originates in the basal cells.

Basal cell carcinoma is the most common type of skin cancer. It arises from abnormal growth of the basal cells, which are found in the deepest layer of the epidermis (skin). Basal cell carcinomas usually appear as pearly or waxy bumps and can be treated effectively with surgery or other therapies.

Medulloblastoma

A type of malignant brain tumor that originates in the cerebellum.

Medulloblastoma is a highly aggressive type of brain tumor that typically affects children. It arises from cells in the cerebellum, a part of the brain responsible for balance and coordination. Medulloblastoma can spread to other parts of the body, making it a serious condition requiring intensive treatment.