RESEARCH: CANCER
FOLDING PROJECT #14948 PROFILE

The project relates to understanding how proteins called Class F Receptors and Patched control cell growth. When these proteins malfunction, they can lead to cancers like Basal Cell Carcinoma and Medulloblastoma. By using computer simulations, researchers hope to learn how these proteins work and find new ways to treat these diseases.

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

A class of G protein-coupled receptors involved in cell signaling.

Class F Receptors are a type of protein found on the surface of cells. They play a crucial role in cell communication and growth regulation. Certain types of cancer are linked to abnormalities in these receptors.

Patched Membrane Protein

A transmembrane protein that acts as a receptor for Hedgehog signaling.

Patched is a protein embedded in the cell membrane. It functions as a sensor for Hedgehog signals, which are important for embryonic development and tissue maintenance. Disruptions in Patched can lead to various developmental abnormalities and cancers.

Basal Cell Carcinoma

A common type of skin cancer that originates in the basal cells.

Basal Cell Carcinoma is a non-melanoma skin cancer that arises from the basal layer of the epidermis. It is typically slow-growing and rarely spreads to other parts of the body. Treatment options include surgery, radiation therapy, or topical medications.

Medulloblastoma

An aggressive type of brain tumor that originates in the cerebellum.

Medulloblastoma is a cancerous tumor that forms in the cerebellum, a part of the brain responsible for coordination and balance. It is most common in children and can be very aggressive. Treatment typically involves surgery, chemotherapy, and radiation therapy.