RESEARCH: CANCER
FOLDING PROJECT #14943 PROFILE

This project looks at how Class F Receptors and Patched proteins control how cells grow and change. These proteins can get overactive or inactive, which is linked to cancer like Basal Cell Carcinoma. By using computer simulations, we hope to understand how these proteins work so we can better learn about and treat these cancers.

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

A class of cell surface receptors involved in signaling pathways.

Class F receptors are a type of protein found on the surface of cells. They play a crucial role in receiving signals from other cells and molecules, influencing processes like cell growth, differentiation, and survival. Imbalances in their function can contribute to diseases like cancer.

Patched Membrane Protein

A protein found on the cell membrane that regulates signaling pathways.

Patched is a protein located on the outer surface of cells. It acts as a brake in certain signaling pathways, preventing excessive activation. Disruptions in Patched function can lead to uncontrolled cell growth and contribute to diseases like cancer.

Basal Cell Carcinoma

A type of skin cancer that originates in the basal cells.

Basal cell carcinoma is a common form of skin cancer that arises from the basal cells, which are located in the deepest layer of the epidermis (outer skin). It often appears as a pearly or waxy bump and can be effectively treated with various methods like surgery or medication.

Medulloblastoma

A type of brain tumor that originates in the cerebellum.

Medulloblastoma is a cancerous growth that develops in the cerebellum, a part of the brain responsible for coordination and balance. It primarily affects children and often requires intensive treatment involving surgery, chemotherapy, and radiation.