RESEARCH: CANCER
FOLDING PROJECT #14959 PROFILE

This project looks at Class F receptors and Patched proteins, which control how cells grow. These proteins can cause problems when they're overactive or inactive, leading to cancers like basal cell carcinoma and medulloblastoma. By using computer simulations, scientists hope to understand how these proteins work so they can better treat these diseases.

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

Group of cell surface receptors involved in signal transduction.

Class F receptors are a type of protein found on the surface of cells. They play an important role in transmitting signals within and between cells. These signals are essential for many cellular processes, including growth, differentiation, and survival.

Patched

A transmembrane protein that acts as a negative regulator of the Hedgehog signaling pathway.

Patched is a protein found on the surface of cells. It plays a role in controlling the Hedgehog signaling pathway, which is important for cell growth and development. When Patched binds to the Hedgehog protein, it inhibits the signaling pathway.

Basal Cell Carcinoma

A common type of skin cancer that arises from the basal cells.

Basal cell carcinoma is a type of skin cancer that begins in the basal cells, which are found in the deepest layer of the epidermis (outer layer of skin). It is often slow-growing and rarely spreads to other parts of the body.

Medulloblastoma

A malignant tumor that originates in the cerebellum.

Medulloblastoma is a type of brain cancer that begins in the cerebellum, a part of the brain responsible for balance and coordination. It is most common in children.