RESEARCH: CANCER
FOLDING PROJECT #14965 PROFILE

This project looks at how proteins called Class F Receptors and Patched work. These proteins help control how cells grow and change. Problems with these proteins can lead to cancers like Basal Cell Carcinoma and Medulloblastoma. By studying how they work, we hope to better understand these diseases.

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

A family of G protein-coupled receptors involved in cell signaling.

Class F Receptors are a group of proteins found on the surface of cells that receive signals from other molecules. These signals can trigger various cellular responses, including changes in growth and differentiation. Dysregulation of Class F Receptor activity has been linked to certain cancers.

Patched

A protein that regulates the activity of Hedgehog signaling pathway.

Patched is a transmembrane protein that acts as a negative regulator of the Hedgehog signaling pathway. This pathway plays a crucial role in embryonic development and tissue homeostasis. Mutations or dysregulation of Patched can lead to uncontrolled cell growth and contribute to the development of various cancers.

Basal Cell Carcinoma

A common type of skin cancer that originates in the basal cells.

Basal cell carcinoma is a slow-growing form of skin cancer that arises from the basal layer of the epidermis. It often presents as pearly or waxy bumps, sometimes with visible blood vessels. While generally less aggressive than other skin cancers, it can spread to surrounding tissues if left untreated.

Medulloblastoma

A malignant brain tumor that originates in the cerebellum.

Medulloblastoma is an aggressive type of childhood brain cancer that develops from cells in the cerebellum, a part of the brain responsible for coordination and balance. It can spread to other parts of the brain and spinal cord. Treatment typically involves surgery, radiation therapy, and chemotherapy.