RESEARCH: CANCER
FOLDING PROJECT #14947 PROFILE

This project looks at two proteins, Class F Receptors and Patched, which control how cells grow and change. When these proteins are messed up, it can lead to cancers like Basal Cell Carcinoma and Medulloblastoma. By using computer simulations, scientists hope to understand how these proteins work so they can find better ways to treat these diseases.

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

Group of cell surface receptors involved in signaling pathways.

Class F Receptors are a type of protein found on the surface of cells. They act as receivers for signals from other cells and molecules, playing a crucial role in regulating various cellular processes, including growth and differentiation. Disruptions in their function can contribute to diseases like cancer.

Patched

A protein that regulates cell growth and development.

Patched is a protein that acts as a brake on cell signaling pathways. It helps control the rate at which cells divide and grow. Mutations in the Patched gene can lead to uncontrolled cell proliferation, contributing to the development of certain cancers.

Basal Cell Carcinoma

A common type of skin cancer that arises from the basal cells.

Basal Cell Carcinoma is the most prevalent form of skin cancer. It develops in the basal cells, which are located in the deepest layer of the epidermis (skin). This cancer often appears as a pearly or waxy bump and can spread to nearby tissues if left untreated.

Medulloblastoma

A type of brain cancer that originates in the cerebellum.

Medulloblastoma is a malignant tumor that arises from the cells of the cerebellum, a part of the brain responsible for balance and coordination. It's often diagnosed in children and can spread rapidly if not treated promptly.

Pathogenesis

The origin and development of a disease.

Pathogenesis refers to the complex series of events leading to the development of a disease. Scientists study pathogenesis to understand how diseases arise, progress, and ultimately lead to symptoms and complications.