RESEARCH: CANCER
FOLDING PROJECT #14952 PROFILE

This project studies how Class F receptors and Patched proteins control cell growth. When these proteins are messed up, it can lead to cancers like Basal Cell Carcinoma and Medulloblastoma. By using computer simulations, we hope to learn how these proteins work so we can better understand and treat these diseases.

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

A family of G protein-coupled receptors involved in cell signaling.

Class F Receptors are a group of proteins on the surface of cells that receive signals from other molecules. These signals help control how cells grow and develop. Dysregulation of Class F Receptors can contribute to diseases like Basal Cell Carcinoma.

Patched

A protein that regulates cell growth and differentiation.

Patched is a protein that acts as a brake on cell growth. When Patched is working properly, it prevents cells from dividing too quickly. However, mutations in the Patched gene can lead to uncontrolled cell growth, which contributes to cancers like Medulloblastoma.

Basal Cell Carcinoma

A type of skin cancer that originates in the basal cells.

Basal Cell Carcinoma is the most common type of skin cancer. It develops in the basal cells, which are found in the deepest layer of the epidermis (outermost skin layer). Early detection and treatment are crucial for successful management.

Medulloblastoma

A type of brain tumor that arises from the cerebellum.

Medulloblastoma is a malignant brain tumor that primarily affects children. It originates in the cerebellum, a region of the brain responsible for balance and coordination. Treatment typically involves surgery, chemotherapy, and radiation therapy.