RESEARCH: CANCER
FOLDING PROJECT #14933 PROFILE

This project looks at Class F Receptors, proteins that help control how cells grow and change. Too much activity in these proteins can cause cancers like Basal Cell Carcinoma and Medulloblastoma. By using computer simulations, researchers hope to understand how these proteins work so they can better study and treat these diseases.

Class F Receptors Class F Receptors are involved in the control of cell differentiation.

Over-activation of these proteins have links to Basal Cell Carcinoma and Medulloblastoma.

Through Simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

Membrane proteins that bind to specific ligands and initiate intracellular signaling cascades.

Class F receptors are a type of protein found on the surface of cells. They act as receptors, binding to specific molecules called ligands. This binding triggers a series of events inside the cell, known as signaling cascades, which ultimately regulate various cellular functions. These receptors play crucial roles in processes like cell growth, differentiation, and survival. Disruptions in their function can contribute to diseases such as cancer.

Basal Cell Carcinoma

A common type of skin cancer that arises from the basal cells in the epidermis.

Basal cell carcinoma is the most prevalent form of skin cancer. It develops from the basal cells, which are located in the deepest layer of the epidermis (the outermost layer of skin). These tumors typically appear as pearly or waxy bumps and often have a visible blood vessel network. Basal cell carcinomas grow slowly and rarely spread to other parts of the body.

Medulloblastoma

A type of malignant brain tumor that originates in the cerebellum.

Medulloblastoma is a highly aggressive form of childhood brain cancer. It arises from cells in the cerebellum, the part of the brain responsible for coordinating movement and balance. Medulloblastomas tend to grow rapidly and can spread to other parts of the nervous system.