RESEARCH: CANCER
FOLDING PROJECT #14940 PROFILE

This project looks at proteins called Class F Receptors and Patched that control how cells develop. Too much or too little of these proteins can cause cancers like Basal Cell Carcinoma and Medulloblastoma. By using computer simulations, scientists hope to learn how these proteins work, which could help us understand and treat these diseases.

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

Membrane receptors that bind ligands and trigger cellular responses.

Class F Receptors are a type of protein found on the surface of cells. They act as receivers for signals from other molecules called ligands. When a ligand binds to a Class F Receptor, it triggers a cascade of events inside the cell, leading to changes in cell behavior. These receptors play important roles in various cellular processes, including growth, differentiation, and survival.

Patched Membrane Protein

A transmembrane protein that regulates the activity of Hedgehog signaling pathway.

Patched is a protein found on the surface of cells. It acts as a negative regulator of the Hedgehog signaling pathway, which is crucial for embryonic development and tissue regeneration. When Hedgehog ligands bind to Patched, it inhibits the activity of another protein called Smoothened, preventing the activation of downstream signaling events.

Basal Cell Carcinoma

A type of skin cancer that originates in the basal cells.

Basal Cell Carcinoma is a common type of skin cancer that arises from the basal cells, which are located in the deepest layer of the epidermis. It typically presents as a pearly or waxy bump, often with visible blood vessels. Basal Cell Carcinoma is usually slow-growing and rarely spreads to other parts of the body.

Medulloblastoma

An aggressive type of brain tumor that originates in the cerebellum.

Medulloblastoma is a malignant brain tumor that arises from the cerebellum, the part of the brain responsible for coordinating movement and balance. It is most commonly diagnosed in children and is characterized by rapid growth and spread. Treatment typically involves surgery, chemotherapy, and radiation therapy.

Pathogenesis

The development or progression of a disease.

Pathogenesis refers to the biological processes that underlie the development and progression of a disease. It encompasses the initial triggers, cellular changes, molecular interactions, and systemic responses involved in the disease process.