RESEARCH: CANCER
FOLDING PROJECT #14958 PROFILE

This project looks at Class F Receptors and Patched proteins which help control how cells grow. When these proteins go wrong, they can cause cancers like Basal Cell Carcinoma and Medulloblastoma. By using computer simulations, we hope to learn how these proteins work so we can better understand these diseases.

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

A family of cell surface receptors involved in signal transduction.

Class F Receptors are a group of proteins found on the surface of cells. They act like antennas, receiving signals from other molecules and triggering changes inside the cell. These signals are important for controlling how cells grow and develop.

Patched

A transmembrane protein that regulates cell growth and differentiation.

Patched is a protein embedded in the membrane of cells. It plays a crucial role in controlling how cells grow and divide. When Patched binds to certain molecules, it can either promote or inhibit cell proliferation.

Basal Cell Carcinoma

A type of skin cancer that originates in the basal cells.

Basal Cell Carcinoma is a common form of skin cancer. It starts in the basal cells, which are located in the deepest layer of the epidermis (the outermost layer of skin). This type of cancer often appears as a pearly or waxy bump on the skin.

Medulloblastoma

A type of brain tumor that originates in the cerebellum.

Medulloblastoma is a malignant brain tumor that develops in the cerebellum, the part of the brain responsible for coordination and balance. It is most common in children.