RESEARCH: CANCER
FOLDING PROJECT #14966 PROFILE

This project looks at proteins called Class F Receptors and Patched that help control how cells develop. When these proteins don't work right, it can lead to cancers like Basal Cell Carcinoma and Medulloblastoma. By using computer simulations, scientists hope to learn how these proteins work so they can better understand and treat these diseases.

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

A group of cell surface receptors involved in signal transduction.

Class F Receptors are a type of protein found on the surface of cells. They act as receptors, receiving signals from other molecules and triggering cellular responses. These receptors play a crucial role in processes like cell growth, differentiation, and survival.

Patched

A transmembrane protein that acts as a negative regulator of the Hedgehog signaling pathway.

Patched is a protein found on the surface of cells. It plays a key role in regulating the Hedgehog signaling pathway, which is important for controlling cell growth and development. When Patched is activated, it inhibits the Hedgehog pathway.

Basal Cell Carcinoma

A type of skin cancer that originates in the basal cells.

Basal Cell Carcinoma is the most common type of skin cancer. It develops from abnormal growth of basal cells, which are found in the deepest layer of the epidermis (outer layer of skin). Basal Cell Carcinoma usually appears as a pearly or waxy bump, and it can sometimes spread to nearby tissues.

Medulloblastoma

A type of malignant brain tumor that arises from the cerebellum.

Medulloblastoma is a type of aggressive brain cancer that originates in the cerebellum, the part of the brain responsible for balance and coordination. It primarily affects children.