RESEARCH: CANCER
FOLDING PROJECT #14963 PROFILE

This project looks at how Class F Receptors and Patched proteins control cell growth. Too much or too little of these proteins can cause cancers like Basal Cell Carcinoma and Medulloblastoma. By using computer simulations, we hope to understand how these proteins work and find new ways to treat these diseases.

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

A group of cell surface receptors involved in signal transduction.

Class F receptors are a family of proteins found on the surface of cells. They play a crucial role in receiving signals from other cells and transmitting them inside the cell. This process is essential for many cellular functions, including growth, differentiation, and survival.

Patched Membrane Protein

A transmembrane protein that acts as a regulator of the Hedgehog signaling pathway.

Patched is a protein embedded in the cell membrane. It's like a gatekeeper for a cellular signaling pathway called the Hedgehog pathway. This pathway is crucial for development and tissue repair, but when it's dysregulated, it can contribute to cancer.

Basal Cell Carcinoma

A type of skin cancer that originates in the basal cells.

Basal cell carcinoma is a common form of skin cancer that starts in the basal cells, which are found in the deepest layer of the epidermis. It's usually slow-growing and rarely spreads to other parts of the body.

Medulloblastoma

A type of malignant brain tumor that originates in the cerebellum.

Medulloblastoma is an aggressive childhood brain tumor that arises from the cerebellum, a part of the brain responsible for balance and coordination. It's often diagnosed in young children and can spread quickly.