RESEARCH: CANCER
FOLDING PROJECT #14949 PROFILE

This project looks at Class F Receptors and Patched proteins, which help control how cells grow and change. When these proteins don't work right, it can lead to cancers like Basal Cell Carcinoma and Medulloblastoma. By using computer simulations, we hope to learn how these proteins work so we can better understand and treat these diseases.

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

Membrane receptors that regulate cell differentiation.

Class F Receptors are a type of protein found on the surface of cells. They play a crucial role in controlling how cells develop and specialize. When these receptors are overactive or inactive, it can lead to problems like Basal Cell Carcinoma and Medulloblastoma, which are types of cancer.

Patched Membrane Protein

A protein involved in signal transduction pathways.

Patched Membrane Protein is another type of protein found on the surface of cells. It acts as a part of signaling pathways that tell cells what to do. Dysfunction of this protein can also contribute to certain cancers.

Basal Cell Carcinoma

A type of skin cancer that originates in the basal cells.

Basal Cell Carcinoma is the most common type of skin cancer. It starts in the bottom layer of the epidermis (the outer layer of skin) and often appears as a pearly or waxy bump.

Medulloblastoma

A type of brain cancer that arises from the cerebellum.

Medulloblastoma is a type of aggressive brain tumor that develops in the cerebellum, the part of the brain responsible for balance and coordination.