RESEARCH: CANCER
FOLDING PROJECT #14957 PROFILE

This project studies how Class F Receptors and Patched proteins control cell growth. When these proteins malfunction, it can lead to cancers like Basal Cell Carcinoma and Medulloblastoma. By using computer simulations, researchers hope to understand how these proteins work and find ways to treat these diseases.

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

A type of receptor protein involved in cell signaling.

Class F receptors are a family of proteins found on the surface of cells. They play a crucial role in receiving and transmitting signals that regulate various cellular processes, including growth, differentiation, and survival. These receptors are essential for maintaining normal tissue development and function.

Patched Membrane Protein

A membrane protein that acts as a negative regulator of the Hedgehog signaling pathway.

Patched is a crucial protein embedded in the cell membrane. Its primary function is to suppress the Hedgehog signaling pathway, which is essential for embryonic development and tissue repair. When Patched is absent or malfunctioning, the Hedgehog pathway becomes overactive, leading to uncontrolled cell growth and potentially cancer.

Basal Cell Carcinoma

A type of skin cancer that originates in the basal cells.

Basal cell carcinoma is the most common form of skin cancer. It arises from the basal cells, which are found in the deepest layer of the epidermis (outer skin layer). Early detection and treatment are crucial to prevent its spread.

Medulloblastoma

A type of malignant brain tumor that arises from the cerebellum.

Medulloblastoma is a rare but aggressive type of brain cancer that primarily affects children. It originates in the cerebellum, a region responsible for coordinating movement and balance. Treatment typically involves surgery, radiation therapy, and chemotherapy.