RESEARCH: CANCER
FOLDING PROJECT #14944 PROFILE

This project studies how Class F Receptors and Patched proteins control cell growth. These proteins are linked to cancer, so figuring out how they work could help us understand and treat diseases like Basal Cell Carcinoma and Medulloblastoma.

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

Receptors that bind to signaling molecules and trigger cellular responses.

Class F receptors are a type of protein found on the surface of cells. They act like antennas, receiving signals from other molecules in the body. These signals can tell cells to grow, divide, or change shape. When these receptors don't work properly, it can lead to problems like cancer.

Patched Membrane Protein

A transmembrane protein that regulates the signaling pathway of Hedgehog.

Patched is a protein found on the surface of cells. It plays an important role in controlling cell growth and development. The Hedgehog pathway is a signaling system that tells cells when to grow, divide, and specialize. Patched acts as a brake on this pathway, preventing cells from growing too quickly. When Patched doesn't work properly, it can lead to uncontrolled cell growth and cancer.

Basal Cell Carcinoma

The most common type of skin cancer.

Basal cell carcinoma is a slow-growing type of skin cancer that starts in the basal cells, which are located in the deepest layer of the epidermis (the outer layer of skin). It usually appears as a pearly or waxy bump on the skin and can grow slowly over time. While it's rarely life-threatening, it can spread to nearby tissues if left untreated.

Medulloblastoma

A type of aggressive brain tumor that develops in the cerebellum.

Medulloblastoma is a fast-growing brain tumor that originates in the cerebellum, which is responsible for coordinating movement and balance. It's most common in children and can spread quickly to other parts of the brain and spinal cord. Treatment typically involves surgery, radiation therapy, and chemotherapy.