RESEARCH: CANCER
FOLDING PROJECT #14938 PROFILE

This project looks at Class F Receptors and Patched proteins. They help control how cells grow and change. When these proteins don't work right, it can lead to cancers like Basal Cell Carcinoma and Medulloblastoma. By using computer simulations, we hope to understand how these proteins work so we can better treat these diseases.

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

Proteins that bind to signaling molecules.

Class F receptors are a type of protein found on the surface of cells. They act as sensors, binding to specific molecules that trigger changes inside the cell. This process is crucial for many cellular functions, including growth, differentiation, and survival.

Patched Membrane Protein

A protein that regulates cell signaling.

Patched is a membrane protein that acts as a negative regulator of the Hedgehog signaling pathway. This pathway plays a critical role in development and tissue homeostasis. Mutations in Patched can lead to overactivation of the pathway, contributing to cancer development.

Basal Cell Carcinoma

A type of skin cancer.

Basal cell carcinoma is the most common type of skin cancer. It arises from the basal cells, which are located in the deepest layer of the epidermis. This cancer typically appears as a pearly or waxy bump and can grow slowly.

Medulloblastoma

A type of brain cancer.

Medulloblastoma is a malignant tumor that originates in the cerebellum, a part of the brain responsible for coordination and balance. This cancer is most common in children.