RESEARCH: CANCER
FOLDING PROJECT #14942 PROFILE

This project looks at Class F Receptors and Patched, proteins that control how cells grow. When these proteins go haywire, they can lead to cancers like Basal Cell Carcinoma and Medulloblastoma. By creating computer models, scientists hope to figure out how these proteins work, which could help us understand and treat these diseases.

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

A family of G protein-coupled receptors involved in cell differentiation.

Class F receptors are a type of protein found on the surface of cells. They act as receptors for signaling molecules and play a crucial role in regulating cell growth and development. When activated, they trigger a cascade of events inside the cell that ultimately influence how cells behave. Disruptions in Class F receptor function can contribute to various diseases, including cancer.

Patched Membrane Protein

A transmembrane protein that regulates the activity of Hedgehog signaling pathway.

Patched is a membrane protein that acts as a 'brake' on the Hedgehog signaling pathway. This pathway is essential for embryonic development and tissue repair. When Patched is functioning correctly, it prevents excessive Hedgehog signaling. However, mutations in Patched can lead to uncontrolled Hedgehog activity, contributing to cancer development.

Basal Cell Carcinoma

A common type of skin cancer that originates in the basal cells.

Basal cell carcinoma is a slow-growing skin cancer that arises from the basal cells, which are located in the deepest layer of the epidermis (the outermost layer of skin). It typically appears as a pearly or waxy bump and can often be treated effectively with surgery or other therapies.

Medulloblastoma

A type of malignant brain tumor that arises from the cerebellum.

Medulloblastoma is a highly aggressive brain tumor that originates in the cerebellum, the part of the brain responsible for coordinating movement and balance. It is most common in children and can spread to other parts of the body if not treated promptly.