RESEARCH: CANCER
FOLDING PROJECT #14964 PROFILE

This project studies Class F Receptors and Patched proteins. These help control how cells grow and change. When they don't work right, it can cause cancers like Basal Cell Carcinoma and Medulloblastoma. By using computer models, we hope to learn how these proteins work so we can better understand and treat these diseases.

Class F Receptors and Patched Membrane Protein Class F Receptors and Patched are human proteins that are involved in the control of cell differentiation.

Over-activation/inactivation of these proteins has links to Basal Cell Carcinoma and Medulloblastoma.

Through simulations we aim to understand the activation mechanisms of these proteins, giving us a way to probe into the pathogenesis of the disease.

Class F Receptors

A group of cell surface receptors involved in signal transduction.

Class F Receptors are a family of proteins found on the surface of cells. They play a crucial role in receiving signals from outside the cell and relaying them to the inside, influencing processes like cell growth, differentiation, and survival. Dysregulation of these receptors is linked to various diseases, including cancers.

Patched Membrane Protein

A transmembrane protein that acts as a receptor for Hedgehog signaling.

Patched is a protein found on the cell surface. It's part of the Hedgehog signaling pathway, which is essential for embryonic development and tissue repair. When Hedgehog binds to Patched, it triggers a cascade of events inside the cell, influencing gene expression and cell behavior. Mutations in Patched are associated with developmental disorders and cancers.

Basal Cell Carcinoma

The most common type of skin cancer, arising from the basal cells.

Basal Cell Carcinoma is a slow-growing form of skin cancer that originates in the basal layer of the epidermis. It often appears as a pearly or waxy bump and can be treated effectively with surgery, radiation therapy, or topical medications.

Medulloblastoma

A malignant tumor that arises in the cerebellum.

Medulloblastoma is a highly aggressive type of brain cancer that primarily affects children. It originates in the cerebellum, which controls balance and coordination. Treatment typically involves surgery, radiation therapy, and chemotherapy.