RESEARCH: LIQUID-PHASE-SEPARATION
FOLDING PROJECT #16577 PROFILE

This project simulates how liquids separate into droplets (like oil and water) when mixed with different molecules. Researchers are studying how adding specific peptides (short proteins) and RNA affects these droplets. The goal is to understand how these droplets form in cells and what role they play in health and disease.

16550: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16551, 16560, 16568: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16552, 16561, 16567: Liquid-liquid Phase separation simulation for condensate and added peptide ARG 16553, 16562, 16569: Liquid-liquid Phase separation simulation for condensate and added peptide LYS 16554: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA 16555, 16577: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA 16556: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA 16557, 16563, 16575: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA, concentration 3.7 mM 16558, 16564, 16566, 16574: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA, concentration 3.7 mM 16559, 16565, 16576: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA, concentration 3.7 mM 16570: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM 16571: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ADMA 16572: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ARG 16573: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide LYS.

Liquid-liquid Phase separation

A process where two liquids form separate phases.

Liquid-liquid phase separation is a natural phenomenon where two immiscible liquids, like oil and water, separate into distinct layers. In biological systems, this process plays a crucial role in forming compartments within cells, such as protein condensates. These condensates can act as hubs for specific cellular functions.

Condensate

A dense, concentrated mixture of molecules.

In biology, a condensate is a highly concentrated region within a cell where specific molecules gather together. These condensates are often formed through liquid-liquid phase separation and can act as platforms for various cellular processes, such as gene regulation or protein synthesis.

Peptide

A short chain of amino acids.

Peptides are small chains of amino acids, the building blocks of proteins. They play diverse roles in biological systems, including signaling molecules, enzymes, and structural components.

ADMA

Arginine dimethyl amino acid

ADMA is a modified form of the amino acid arginine that can influence blood vessel dilation and cell signaling. Its role in various physiological processes is under investigation.

ARG

Arginine

Arginine is an essential amino acid involved in protein synthesis, wound healing, and the production of nitric oxide, which regulates blood flow.

LYS

Lysine

Lysine is an essential amino acid crucial for protein synthesis, bone health, and the production of certain hormones.

RNA

Ribonucleic acid

RNA is a molecule essential for protein synthesis. It carries genetic information from DNA to ribosomes, where proteins are made.