RESEARCH: LIQUID-PHASE-SEPARATION
FOLDING PROJECT #16576 PROFILE

This project simulates how tiny protein clumps called condensates change when different peptides (small proteins) are added. They look at how these changes affect the clump's size and shape, especially when RNA is also included. Different concentrations of peptides and RNA are tested to see how it impacts the clumps.

Note: This TLDR is a simplication and may not be 100% accurate.

16550: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16551, 16560, 16568: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16552, 16561, 16567: Liquid-liquid Phase separation simulation for condensate and added peptide ARG 16553, 16562, 16569: Liquid-liquid Phase separation simulation for condensate and added peptide LYS 16554: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA 16555, 16577: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA 16556: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA 16557, 16563, 16575: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA, concentration 3.7 mM 16558, 16564, 16566, 16574: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA, concentration 3.7 mM 16559, 16565, 16576: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA, concentration 3.7 mM 16570: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM 16571: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ADMA 16572: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ARG 16573: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide LYS.

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Liquid-liquid Phase separation

Separation of components in a liquid based on their solubility

Liquid-liquid phase separation is a process where different molecules within a liquid mixture separate into distinct phases due to variations in their solubility. This phenomenon plays a crucial role in various biological processes, including the formation of organelles, protein aggregation, and gene regulation.

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Condensate

A dense, concentrated substance that forms when molecules aggregate together

Condensates are dense, concentrated regions within a cell or solution formed by the aggregation of specific molecules. They can play crucial roles in regulating cellular processes and compartmentalizing various functions.

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Peptide

A short chain of amino acids linked together

Peptides are short chains of amino acids, the building blocks of proteins. They often play vital roles in biological processes, acting as hormones, neurotransmitters, and signaling molecules.

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ADMA

Asparagine-Derived Methylarginine

ADMA is a molecule derived from the amino acid asparagine and plays a role in regulating blood pressure.

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ARG

Arginine

ARG is an acronym for the amino acid arginine, which plays important roles in protein structure and function.

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LYS

Lysine

LYS is an acronym for the amino acid lysine, which is essential for various biological processes.

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RNA

Ribonucleic Acid

RNA is a type of nucleic acid that plays a vital role in protein synthesis and other cellular processes.

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mM

Millimolar

mM stands for millimolar, a unit of concentration used to express the amount of solute in a solution.