RESEARCH: PHASE-SEPARATION-SIMULATION
FOLDING PROJECT #16558 PROFILE

This project simulates how droplets form inside cells when different molecules like peptides and RNA mix. Researchers are testing how adding specific peptides (ADMA, ARG, LYS) affects these droplets. They're also looking at how the concentration of molecules influences droplet formation.

16550: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16551, 16560, 16568: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16552, 16561, 16567: Liquid-liquid Phase separation simulation for condensate and added peptide ARG 16553, 16562, 16569: Liquid-liquid Phase separation simulation for condensate and added peptide LYS 16554: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA 16555, 16577: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA 16556: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA 16557, 16563, 16575: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA, concentration 3.7 mM 16558, 16564, 16566, 16574: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA, concentration 3.7 mM 16559, 16565, 16576: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA, concentration 3.7 mM 16570: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM 16571: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ADMA 16572: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ARG 16573: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide LYS.

Liquid-liquid Phase separation

The process where two immiscible liquids separate into distinct phases.

Liquid-liquid phase separation is a natural phenomenon where two liquids that don't mix, like oil and water, form separate layers. In biology, this plays a crucial role in how cells organize their components and carry out essential functions.

Condensate

A concentrated solution or mixture that forms a distinct phase.

In biology, a condensate is like a dense clump of molecules that form within a cell. These clumps can group specific proteins or RNA together, helping them perform their jobs more efficiently.

Peptide

A short chain of amino acids linked together.

Peptides are like tiny building blocks made up of amino acids. They can have various functions in the body, such as signaling between cells or acting as enzymes.

ADMA

Asparagine-dimethylarginine

ADMA is a molecule that can interfere with the activity of an enzyme called nitric oxide synthase. This enzyme is important for regulating blood pressure and other bodily functions.

ARG

Arginine

Arginine is an amino acid that plays various roles in the body, including protein synthesis and wound healing.

LYS

Lysine

Lysine is an essential amino acid that is important for growth and development. It also plays a role in the production of certain hormones and enzymes.

RNA

Ribonucleic acid

RNA is a molecule similar to DNA that plays many important roles in the cell. It carries genetic information from DNA to ribosomes, where proteins are made.