RESEARCH: LIQUID-PHASE-SEPARATION
FOLDING PROJECT #16567 PROFILE

This project looks at how different molecules mix and separate in liquids. Researchers are studying something called 'liquid-liquid phase separation' to see how it works with mixtures containing peptides (short proteins) like ADMA, ARG, and LYS, along with RNA. They're also exploring how the concentration of these molecules affects the separation process.

16550: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16551, 16560, 16568: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16552, 16561, 16567: Liquid-liquid Phase separation simulation for condensate and added peptide ARG 16553, 16562, 16569: Liquid-liquid Phase separation simulation for condensate and added peptide LYS 16554: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA 16555, 16576: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA 16556: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA 16557, 16563, 16572: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA, concentration 3.7 mM 16558, 16564, 16566, 16571: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA, concentration 3.7 mM 16559, 16565, 16573: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA, concentration 3.7 mM 16570.

Liquid-liquid Phase separation

The process where two liquids form distinct phases due to differences in solubility.

Liquid-liquid phase separation is a natural phenomenon where two immiscible liquids, often components within cells, separate into distinct layers. This plays a crucial role in various cellular processes like protein aggregation and the formation of membraneless organelles.

Condensate

A concentrated solution or deposit formed by the separation of components in a mixture.

In biological systems, condensates are dense, gel-like compartments within cells that form through liquid-liquid phase separation. They play vital roles in organizing cellular processes and concentrating specific molecules.

Peptide

A short chain of amino acids linked together by peptide bonds.

Peptides are small protein fragments composed of a few to several dozen amino acids. They play diverse roles in biological systems, including signaling, enzymatic activity, and structural support.

ADMA

asymmetric dimethylarginine

ADMA is an amino acid derivative that can inhibit nitric oxide synthase, an enzyme crucial for blood vessel dilation. Elevated ADMA levels are linked to cardiovascular disease.

ARG

Arginine

Arginine is an amino acid essential for various biological processes, including protein synthesis, wound healing, and immune function.

LYS

Lysine

Lysine is an essential amino acid crucial for protein synthesis, collagen production, and the absorption of calcium.

RNA

Ribonucleic Acid

RNA is a nucleic acid essential for protein synthesis and gene expression. It plays various roles in cellular processes, including carrying genetic information from DNA to ribosomes.