RESEARCH: LIQUID-PHASE-SEPARATION
FOLDING PROJECT #16569 PROFILE

This project looks at how different small proteins (peptides) affect the clumping together of molecules inside cells, a process called liquid-liquid phase separation. Researchers simulated how peptides like ADMA, ARG, and LYS change the clumping when added to a mix of existing cellular molecules, both alone and with RNA. They also studied how changing the concentration of these peptides affects the clumping.

16550: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16551, 16560, 16568: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16552, 16561, 16567: Liquid-liquid Phase separation simulation for condensate and added peptide ARG 16553, 16562, 16569: Liquid-liquid Phase separation simulation for condensate and added peptide LYS 16554: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA 16555: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA 16556: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA 16557, 16563, 16566: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA, concentration 3.7 mM 16558, 16564 : Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA, concentration 3.7 mM 16559, 16565: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA, concentration 3.7 mM.

Liquid-liquid Phase separation

A process where components in a solution separate into two immiscible phases based on their solubility.

Liquid-liquid phase separation is a natural phenomenon where molecules in a solution cluster together due to differences in their affinity for water. This can lead to the formation of distinct liquid droplets within the solution, often influencing cellular processes and biological functions.

Condensate

A concentrated substance or solution, often formed by a process of phase separation.

In biological contexts, condensates are droplet-like structures formed within cells when certain molecules clump together due to interactions. These condensates can serve as platforms for specific biochemical reactions and play roles in various cellular processes.

Peptide

A short chain of amino acids linked together by peptide bonds.

Peptides are small protein fragments composed of a few to several dozen amino acids. They perform diverse functions in the body, including signaling, enzymatic activity, and structural support.

ADMA

Aspartic acid methyl ester

ADMA is a specific amino acid derivative that has been studied for its potential role in regulating blood pressure and other physiological processes.

ARG

Arginine

ARG is a common amino acid found in proteins. It plays essential roles in various cellular functions, including protein synthesis and signaling.

LYS

Lysine

LYS is another crucial amino acid that participates in protein structure and numerous cellular processes, including DNA replication and repair.

RNA

Ribonucleic acid

RNA is a vital nucleic acid that plays various roles in cellular processes, including protein synthesis and genetic regulation.