RESEARCH: LIQUID-PHASE-SEPARATION
FOLDING PROJECT #16564 PROFILE

This project simulates how tiny drops of liquid inside cells (called condensates) change when different molecules are added. They tested adding peptides ADMA, ARG, and LYS, as well as RNA, to see how it affects the drop's shape and size. Different concentrations were also tested to understand how much molecule matters.

16550: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16551, 16560, 16568: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16552, 16561, 16567: Liquid-liquid Phase separation simulation for condensate and added peptide ARG 16553, 16562, 16569: Liquid-liquid Phase separation simulation for condensate and added peptide LYS 16554: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA 16555, 16577: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA 16556: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA 16557, 16563, 16575: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA, concentration 3.7 mM 16558, 16564, 16566, 16574: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA, concentration 3.7 mM 16559, 16565, 16576: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA, concentration 3.7 mM 16570: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM 16571: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ADMA 16572: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ARG 16573: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide LYS.

Liquid-liquid Phase separation

The process where two immiscible liquids separate.

Liquid-liquid phase separation is a natural process where two liquids that don't mix form distinct layers. In biology, this happens when molecules like proteins or RNA clump together and become separated from the surrounding liquid.

Condensate

A dense, concentrated phase of molecules that forms from a solution.

A condensate is like a little clump of molecules in a cell. These clumps can form when molecules stick together because of their attraction to each other. They are important for many processes inside cells.

Peptide

A short chain of amino acids linked together.

Peptides are like mini proteins. They are made up of a few amino acids joined together. They have many important jobs in the body, like carrying messages between cells or helping with chemical reactions.

ADMA

Aspartic Acid Methyl Ester

ADMA is a chemical modification of the amino acid aspartic acid. It's used in research to study how cells interact and build structures.

ARG

Arginine

ARG is the abbreviation for arginine, a crucial amino acid involved in many biological processes, such as protein synthesis and wound healing.

LYS

Lysine

LYS stands for lysine, another essential amino acid that plays a role in building proteins and producing hormones.

RNA

Ribonucleic Acid

RNA is a molecule that carries genetic information and helps make proteins. It's essential for many cellular processes.