RESEARCH: LIQUID-PHASE-SEPARATION
FOLDING PROJECT #16561 PROFILE

This project uses computer simulations to study how liquids separate into different parts (like oil and water) when certain molecules are added. The simulations focus on a special kind of liquid called a 'condensate' found in cells, and explore how adding peptides like ADMA, ARG, and LYS, as well as RNA, affects the separation process. The researchers change things like concentration and types of molecules to see how it impacts the outcome.

16550: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16551, 16560, 16568: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16552, 16561, 16567: Liquid-liquid Phase separation simulation for condensate and added peptide ARG 16553, 16562, 16569: Liquid-liquid Phase separation simulation for condensate and added peptide LYS 16554: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA 16555, 16577: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA 16556: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA 16557, 16563, 16575: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA, concentration 3.7 mM 16558, 16564, 16566, 16574: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA, concentration 3.7 mM 16559, 16565, 16576: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA, concentration 3.7 mM 16570: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM 16571: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ADMA 16572: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ARG 16573: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide LYS.

Liquid-liquid Phase separation

The process where two immiscible liquids separate into distinct phases.

Liquid-liquid phase separation is a natural phenomenon where two liquids that don't mix naturally form separate layers. This happens in biological systems too, like when proteins clump together to form compartments within cells.

Condensate

A concentrated or dense phase of matter, often formed by the aggregation of molecules.

A condensate is like a thick, concentrated blob of molecules that come together in a specific way. In biology, they are important for organizing cellular processes and storing information.

Peptide

A short chain of amino acids linked together by peptide bonds.

Peptides are like building blocks for proteins. They are made up of many smaller units called amino acids, and they can perform various functions in the body.

ADMA

Aspartate-derived methylarginine

ADMA is a molecule that can affect the function of certain proteins involved in blood vessel health. Researchers study its role in various diseases.

ARG

Arginine

Arginine is an amino acid that plays a crucial role in various biological processes. It's involved in protein synthesis, wound healing, and immune function.

LYS

Lysine

Lysine is another essential amino acid involved in protein synthesis, enzyme function, and the absorption of calcium.

RNA

Ribonucleic acid

RNA is a molecule similar to DNA that plays a crucial role in protein synthesis and gene expression. There are different types of RNA, each with specific functions.