RESEARCH: LIQUID-PHASE-SEPARATION
FOLDING PROJECT #16565 PROFILE

This project simulates how liquids separate into different layers when mixing certain molecules. The researchers look at how adding peptides like ADMA, ARG, and LYS affects these separations, especially when combined with RNA.

16550: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16551, 16560, 16568: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16552, 16561, 16567: Liquid-liquid Phase separation simulation for condensate and added peptide ARG 16553, 16562, 16569: Liquid-liquid Phase separation simulation for condensate and added peptide LYS 16554: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA 16555, 16577: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA 16556: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA 16557, 16563, 16575: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA, concentration 3.7 mM 16558, 16564, 16566, 16574: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA, concentration 3.7 mM 16559, 16565, 16576: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA, concentration 3.7 mM 16570: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM 16571: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ADMA 16572: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ARG 16573: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide LYS.

Liquid-liquid Phase separation

Process where molecules separate into two liquid phases based on solubility.

Liquid-liquid phase separation is a process where molecules in a solution spontaneously divide into two distinct liquid phases. This often happens due to differences in solubility, where some molecules prefer to clump together while others remain dispersed. This plays a crucial role in various biological processes like the formation of cellular structures and the regulation of gene expression.

Condensate

A concentrated mixture of molecules that forms a distinct phase.

In biology, a condensate is a dense, separated region within a cell where specific molecules cluster together. These regions often form spontaneously due to interactions between molecules and play important roles in cellular functions like regulating gene expression and organizing cellular processes.

Peptide

A short chain of amino acids linked together.

Peptides are chains of amino acids, the building blocks of proteins. They can have various functions in the body, acting as signaling molecules, hormones, or components of larger proteins. The specific sequence of amino acids determines a peptide's unique properties and function.

ADMA

Aspartate-arginine methyl amino acid

ADMA is a naturally occurring molecule in the body that can interfere with blood vessel function. It's a type of amino acid derivative, and its levels are often measured as an indicator of cardiovascular health.

ARG

Arginine

Arginine is an amino acid that plays many roles in the body. It's involved in protein synthesis, wound healing, and the production of nitric oxide, which helps relax blood vessels.

LYS

Lysine

Lysine is an essential amino acid that the body needs to obtain from food. It's important for building proteins, producing hormones and enzymes, and maintaining healthy bones.

RNA

Ribonucleic acid; a nucleic acid that carries genetic information.

RNA is a molecule essential for many cellular processes. It plays a vital role in protein synthesis by carrying genetic information from DNA to ribosomes, where proteins are made. Different types of RNA have specialized functions in the cell, including messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA).