RESEARCH: LIQUID-PHASE-SEPARATION
FOLDING PROJECT #16573 PROFILE

This project simulates how tiny drops of liquid inside cells (called condensates) change when we add different proteins and RNA. They look at how these additions affect the shape and size of the drops, which is important for understanding cell processes like protein production.

16550: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16551, 16560, 16568: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16552, 16561, 16567: Liquid-liquid Phase separation simulation for condensate and added peptide ARG 16553, 16562, 16569: Liquid-liquid Phase separation simulation for condensate and added peptide LYS 16554: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA 16555, 16577: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA 16556: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA 16557, 16563, 16575: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA, concentration 3.7 mM 16558, 16564, 16566, 16574: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA, concentration 3.7 mM 16559, 16565, 16576: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA, concentration 3.7 mM 16570: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM 16571: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ADMA 16572: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ARG 16573: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide LYS.

Phase separation

Process where molecules separate into different phases based on their properties.

Phase separation is a process where different types of molecules in a solution clump together and form distinct layers. This often happens because molecules with similar properties stick to each other more than they do to different types of molecules. It's important in many biological processes, like how proteins organize inside cells.

Condensate

A concentrated mixture of molecules, often formed through phase separation.

Condensate is a dense clump of molecules that form when they cluster together. Think of it like oil and water separating; the oil forms a separate layer because its molecules stick together more than they do with water. In cells, condensates help organize proteins and RNA to carry out specific tasks.

Peptide

A short chain of amino acids linked together.

Peptides are like little chains made of building blocks called amino acids. They're important because they can fold into specific shapes that allow them to do different jobs in the body. Some peptides act as hormones, others help fight infections, and some even help build tissues.

ADMA

Asymmetric Dimethylarginine

ADMA is a naturally occurring molecule that can affect blood vessel function. High levels of ADMA are associated with an increased risk of heart disease.

ARG

Arginine

Arginine is an amino acid that plays a role in many important processes in the body, including protein synthesis, wound healing, and immune function.

LYS

Lysine

Lysine is an essential amino acid that plays a role in protein synthesis, calcium absorption, and the production of hormones and enzymes.

RNA

Ribonucleic acid

RNA is a molecule that plays many crucial roles in the cell. It helps carry genetic information from DNA to ribosomes, where proteins are made. There are different types of RNA, each with a specific function.