RESEARCH: LIQUID-PHASE-SEPARATION
FOLDING PROJECT #16572 PROFILE

This project simulates how liquid droplets inside cells change when different molecules like peptides (ADMA, ARG, LYS) and RNA are added. It explores how these changes affect the formation and structure of these droplets at various concentrations.

Note: This TLDR is a simplication and may not be 100% accurate.

16550: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16551, 16560, 16568: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16552, 16561, 16567: Liquid-liquid Phase separation simulation for condensate and added peptide ARG 16553, 16562, 16569: Liquid-liquid Phase separation simulation for condensate and added peptide LYS 16554: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA 16555, 16577: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA 16556: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA 16557, 16563, 16575: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA, concentration 3.7 mM 16558, 16564, 16566, 16574: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA, concentration 3.7 mM 16559, 16565, 16576: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA, concentration 3.7 mM 16570: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM 16571: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ADMA 16572: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ARG 16573: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide LYS.

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Phase separation

The process of separating different components of a solution based on their solubility.

Phase separation is a natural process where molecules in a mixture tend to separate into distinct regions due to differences in their properties like solubility. This can happen in biological systems, leading to the formation of compartments within cells.

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Condensate

A concentrated mixture of molecules that forms a distinct phase within a solution.

In biochemistry, a condensate is a dense region formed by the aggregation of molecules within a cell. These compartments can play important roles in regulating cellular processes.

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Peptide

A short chain of amino acids linked together.

Peptides are chains of amino acids, the building blocks of proteins. They can have diverse functions in biological systems, including acting as hormones, neurotransmitters, and structural components.

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ADMA

Asymmetric dimethylarginine

ADMA is a naturally occurring amino acid derivative that can inhibit the activity of nitric oxide synthase, an enzyme involved in vasodilation.

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ARG

Arginine

Arginine is an amino acid that plays a role in various biological processes, including protein synthesis and the production of nitric oxide.

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LYS

Lysine

Lysine is an essential amino acid that plays a role in protein synthesis, tissue repair, and the absorption of calcium.

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RNA

Ribonucleic acid

RNA is a type of nucleic acid that plays a crucial role in protein synthesis. It carries genetic information from DNA to ribosomes, where proteins are made.

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mM

millimolar

mM is a unit of concentration that represents the number of moles of solute per liter of solution. It's commonly used in chemistry and biochemistry to express the amount of substances dissolved in solutions.