RESEARCH: LIQUID-PHASE-SEPARATION
FOLDING PROJECT #16555 PROFILE

This project uses computer simulations to study how different molecules clump together inside cells. They're looking at how adding specific peptides (small proteins) changes these clumps, especially when RNA is also present. Simulations vary the types and amounts of peptides and RNA to see how it affects clump formation.

16550: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16551, 16560, 16568: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16552, 16561, 16567: Liquid-liquid Phase separation simulation for condensate and added peptide ARG 16553, 16562, 16569: Liquid-liquid Phase separation simulation for condensate and added peptide LYS 16554: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA 16555, 16577: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA 16556: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA 16557, 16563, 16575: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA, concentration 3.7 mM 16558, 16564, 16566, 16574: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA, concentration 3.7 mM 16559, 16565, 16576: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA, concentration 3.7 mM 16570: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM 16571: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ADMA 16572: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ARG 16573: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide LYS.

Liquid-liquid Phase separation

The process of two immiscible liquids separating into distinct phases.

Liquid-liquid phase separation is a natural phenomenon where two liquids that don't mix form separate layers. In biology, it plays a crucial role in forming structures within cells called condensates, which are involved in various processes like gene expression and protein synthesis.

Condensate

A dense, concentrated phase of molecules within a cell.

Condensates are like tiny droplets formed within cells where specific proteins and RNA molecules clump together. These droplets act as compartments for important cellular processes like gene regulation and protein synthesis.

Peptide

A short chain of amino acids linked together.

Peptides are like building blocks made up of chains of amino acids. They have various functions in the body, including signaling molecules, hormones, and components of larger proteins.

ADMA

Aspartic Acid Methyl Ester Analog

ADMA is a modified amino acid that can affect various biological processes. Research investigates its role in cell signaling and its potential implications in diseases.

ARG

Arginine

Arginine is an amino acid important for protein synthesis and various biological functions. It plays a role in cell division, wound healing, and immune responses.

LYS

Lysine

Lysine is an essential amino acid crucial for protein synthesis and various bodily functions. It helps in the absorption of calcium, supports immune function, and is involved in energy production.

RNA

Ribonucleic acid

RNA is a vital molecule involved in various cellular processes. It carries genetic information from DNA to ribosomes, where proteins are synthesized. Different types of RNA play specific roles in gene expression and regulation.