RESEARCH: PHASE-SEPARATION-SIMULATION
FOLDING PROJECT #16557 PROFILE

This project simulates how liquid droplets (condensates) change when adding different peptides (proteins). They tested three types of peptides: ADMA, ARG, and LYS. The simulations also looked at the effect of adding RNA to the droplets. The project varied the concentration of these components to see how it affects the droplet behavior.

16550: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16551, 16560, 16568: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16552, 16561, 16567: Liquid-liquid Phase separation simulation for condensate and added peptide ARG 16553, 16562, 16569: Liquid-liquid Phase separation simulation for condensate and added peptide LYS 16554: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA 16555, 16577: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA 16556: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA 16557, 16563, 16575: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA, concentration 3.7 mM 16558, 16564, 16566, 16574: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA, concentration 3.7 mM 16559, 16565, 16576: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA, concentration 3.7 mM 16570: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM 16571: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ADMA 16572: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ARG 16573: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide LYS.

Liquid-liquid Phase separation

The process by which two immiscible liquids separate into distinct phases.

Liquid-liquid phase separation is a natural phenomenon where two liquids that don't mix, like oil and water, form distinct layers. This happens in cells too, where molecules can clump together to form different compartments.

Condensate

A concentrated mixture of substances.

In biology, a condensate is a clump of molecules that form together in a cell. These clumps can be important for organizing different processes and reactions within the cell.

Peptide

A short chain of amino acids.

Peptides are like small chains of building blocks called amino acids. They're important for many functions in the body, like sending messages between cells or helping with digestion.

ADMA

Aspartate-arginine methyltransferase inhibitor

ADMA is a drug that blocks an enzyme called arginase. Arginase plays a role in the metabolism of arginine, an amino acid important for many bodily functions.

ARG

Arginine

ARG is short for arginine, an amino acid that plays important roles in many bodily processes, such as protein synthesis and muscle function.

LYS

Lysine

LYS stands for lysine, another essential amino acid that is crucial for building proteins and supporting various bodily functions.

RNA

Ribonucleic acid

RNA is a molecule similar to DNA that plays many roles in the cell. It helps build proteins and carries genetic information.