RESEARCH: LIQUID-PHASE-SEPARATION
FOLDING PROJECT #16570 PROFILE

This project simulates how different molecules clump together in a cell. They looked at how adding certain peptides (ADMA, ARG, LYS) and RNA to existing clumps affects their size and shape. Some simulations included higher concentrations of these molecules.

16550: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16551, 16560, 16568: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16552, 16561, 16567: Liquid-liquid Phase separation simulation for condensate and added peptide ARG 16553, 16562, 16569: Liquid-liquid Phase separation simulation for condensate and added peptide LYS 16554: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA 16555, 16577: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA 16556: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA 16557, 16563, 16575: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA, concentration 3.7 mM 16558, 16564, 16566, 16574: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA, concentration 3.7 mM 16559, 16565, 16576: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA, concentration 3.7 mM 16570: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM 16571: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ADMA 16572: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ARG 16573: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide LYS.

Liquid-liquid Phase separation

The process where two immiscible liquids separate into distinct phases.

Liquid-liquid phase separation is a natural phenomenon where two liquids that don't mix, like oil and water, form separate layers. In biochemistry, this process is important for how cells organize their components and carry out essential functions.

Condensate

A concentrated mixture of molecules in a cellular context.

In biology, a condensate is like a dense drop or clump formed by molecules grouping together. These condensates are important for organizing cell functions and carrying out specific processes.

Peptide

A short chain of amino acids linked together.

Peptides are like mini proteins made up of a few building blocks called amino acids. They play many important roles in the body, such as signaling and carrying out specific functions.

ADMA

Asparagine-derived methylarginine analog.

ADMA is a molecule that acts like a natural protein in the body. Scientists use it to study how proteins affect cellular processes.

ARG

Arginine.

ARG is a shortened form of the amino acid arginine. Arginine plays several roles in the body, including building proteins and supporting muscle growth.

LYS

Lysine.

LYS is a shortened form of the amino acid lysine. Lysine is important for building proteins and helping the body absorb calcium.

RNA

Ribonucleic acid.

RNA is a molecule that plays a crucial role in carrying genetic information from DNA to the parts of the cell that make proteins.