RESEARCH: LIQUID-PHASE-SEPARATION
FOLDING PROJECT #16568 PROFILE

This project simulates how liquids separate into different parts (like oil and water) when certain molecules are added. Researchers looked at how adding specific peptides (small proteins) affects this separation, both with and without RNA (genetic material).

16550: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16551, 16560, 16568: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16552, 16561, 16567: Liquid-liquid Phase separation simulation for condensate and added peptide ARG 16553, 16562, 16569: Liquid-liquid Phase separation simulation for condensate and added peptide LYS 16554: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA 16555, 16576: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA 16556: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA 16557, 16563, 16572: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA, concentration 3.7 mM 16558, 16564, 16566, 16571: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA, concentration 3.7 mM 16559, 16565, 16573: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA, concentration 3.7 mM 16570.

Liquid-liquid Phase separation

The process by which two immiscible liquids separate into distinct phases.

Liquid-liquid phase separation is a natural phenomenon where two liquids, unable to mix, divide into layers. This is important in biology because many cellular processes involve the formation of distinct compartments within cells using this principle.

Condensate

A concentrated solution or mixture of substances, often formed by phase separation.

In biology, a condensate is a dense, droplet-like structure within cells that forms when certain molecules clump together. These droplets can play important roles in organizing cellular processes and storing information.

Peptide

A short chain of amino acids linked together.

Peptides are like tiny chains made up of building blocks called amino acids. They play many crucial roles in the body, including carrying signals, defending against infections, and helping to build and repair tissues.

ADMA

Aspartate-dimethylarginine dimethylaminohydrolase (amino acid metabolism)

ADMA is a molecule that can affect blood vessel function. It's related to the metabolism of amino acids and plays a role in how our blood vessels expand and contract.

ARG

Arginine (amino acid)

Arginine is an essential amino acid that our bodies need to function properly. It's involved in many processes, including building proteins, producing nitric oxide (which helps blood vessels relax), and supporting the immune system.

LYS

Lysine (amino acid)

Lysine is another essential amino acid that plays a vital role in building proteins, producing enzymes, and supporting healthy growth and development.

RNA

Ribonucleic acid, a nucleic acid that plays a crucial role in protein synthesis.

RNA is a molecule essential for making proteins. It carries genetic information from DNA to the ribosomes, where proteins are built.