RESEARCH: LIQUID-PHASE-SEPARATION
FOLDING PROJECT #16571 PROFILE

This project simulates how liquid droplets form in cells when adding different peptides (proteins) like ADMA, ARG, and LYS. It explores how these peptides interact with RNA molecules within these droplets at various concentrations. The simulations help understand how these droplets change and function differently depending on the types and amounts of molecules present.

Note: This TLDR is a simplication and may not be 100% accurate.

16550: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16551, 16560, 16568: Liquid-liquid Phase separation simulation for condensate and added peptide ADMA 16552, 16561, 16567: Liquid-liquid Phase separation simulation for condensate and added peptide ARG 16553, 16562, 16569: Liquid-liquid Phase separation simulation for condensate and added peptide LYS 16554: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA 16555, 16577: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA 16556: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA 16557, 16563, 16575: Liquid-liquid Phase separation simulation for condensate containing peptide ADMA and RNA, concentration 3.7 mM 16558, 16564, 16566, 16574: Liquid-liquid Phase separation simulation for condensate containing peptide ARG and RNA, concentration 3.7 mM 16559, 16565, 16576: Liquid-liquid Phase separation simulation for condensate containing peptide LYS and RNA, concentration 3.7 mM 16570: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM 16571: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ADMA 16572: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide ARG 16573: Liquid-liquid Phase separation simulation for condensate containing 16 peptide ARG and 16 RNA molecules, concentration 7.4 mM with an additional peptide LYS.

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Liquid-liquid Phase separation

Separation of components based on their solubility in two immiscible liquids.

Liquid-liquid phase separation is a process where molecules separate into distinct liquid phases based on their solubility. This phenomenon plays a crucial role in various cellular processes, including protein assembly and RNA localization.

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Condensate

A concentrated mixture of molecules that forms a distinct phase.

In biological systems, condensates are dense, localized areas where molecules like proteins and RNA gather together. This aggregation is driven by interactions between the molecules and can facilitate various cellular functions.

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Peptide

A short chain of amino acids linked together.

Peptides are chains of amino acids, the building blocks of proteins. They can have diverse functions, acting as signaling molecules, enzymes, or structural components.

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ADMA

Aspartic acid methyl ester analogue

ADMA is a modified amino acid often used in research to study protein interactions and cellular processes.

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ARG

Arginine

ARG is an acronym for the amino acid arginine, which plays various roles in biological systems, including protein structure and signaling.

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LYS

Lysine

LYS represents the amino acid lysine, essential for protein synthesis and various cellular functions.

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RNA

Ribonucleic acid

RNA is a nucleic acid essential for protein synthesis and various cellular processes. It plays diverse roles, including carrying genetic information and regulating gene expression.

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mM

Millimolar

mM stands for millimolar, a unit of concentration expressing the number of moles of a substance per liter of solution.