RESEARCH: CANCER
FOLDING PROJECT #12015 PROFILE

This project relates to Class A GPCRs, which are important targets for many medicines. These proteins act like cellular communication systems, sending signals within the body. Understanding how they work can help create new drugs to treat diseases like cancer, diabetes, depression, and anxiety.

Class A GPCRs: Class A GPCRs are pivotal drug targets in our body, as they are involved in regulating almost all homeostatic processes in the human body.

It is estimated that around 35% of all drugs currently approved by the FDA target one of these GPCRs.

These proteins act like 'molecular telephones' and transmit signals from outside the cell to inside the cell.

Here, we aim to study the process that underlies their action on our body.

This is integral for providing insights into the protein's function and design better and new drugs targeting cancer, diabetes, depression and anxiety.

GPCR

G Protein-Coupled Receptor

GPCRs are a large family of proteins found on the surface of cells that bind to signaling molecules. They play a crucial role in transmitting signals within the body and are involved in a wide range of physiological processes.

FDA

Food and Drug Administration

The FDA is a government agency responsible for ensuring the safety and efficacy of drugs and other medical products in the United States.

Cancer

A disease characterized by uncontrolled cell growth and spread.

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. It arises from genetic mutations that disrupt normal cell division and death.

Diabetes

A metabolic disorder characterized by high blood sugar levels.

Diabetes occurs when the body either doesn't produce enough insulin or can't effectively use the insulin it produces. Insulin is a hormone that regulates blood sugar levels. This leads to elevated glucose levels in the bloodstream, potentially damaging organs and tissues.

Depression

A mood disorder characterized by persistent feelings of sadness, hopelessness, and loss of interest.

Depression is a common mental health disorder affecting millions worldwide. It involves prolonged periods of low mood, loss of energy, difficulty concentrating, and changes in sleep and appetite. Treatment often involves therapy, medication, or a combination of both.

Anxiety

A feeling of unease, worry, or fear.

Anxiety is a normal human emotion but can become problematic when it's excessive and persistent. It often involves physical symptoms like rapid heartbeat, sweating, and difficulty breathing. There are various types of anxiety disorders, such as generalized anxiety disorder and social anxiety disorder.