RESEARCH: CANCER
FOLDING PROJECT #12005 PROFILE

This project looks at how Class A GPCRs work in our bodies. These proteins act like messengers, sending signals that control many important processes. Understanding them better could lead to new drugs for diseases like cancer, diabetes, and depression.

Note: This TLDR is a simplication and may not be 100% accurate.

Class A GPCRs: Class A GPCRs are pivotal drug targets in our body, as they are involved in regulating almost all homeostatic processes in the human body.

It is estimated that around 35% of all drugs currently approved by the FDA target one of these GPCRs.

These proteins act like 'molecular telephones' and transmit signals from outside the cell to inside the cell.

Here, we aim to study the process that underlies their action on our body.

This is integral for providing insights into the protein's function and design better and new drugs targeting cancer, diabetes, depression and anxiety.

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GPCRs

G Protein-Coupled Receptors

G protein-coupled receptors (GPCRs) are a large family of cell surface receptors that play crucial roles in transmitting signals from outside the cell to inside. They are involved in various physiological processes, making them important drug targets for treating diseases like cancer, diabetes, and depression.

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Drug Targets

Molecules or biological pathways that are the focus of drug action.

Drug targets are specific molecules or processes within the body that medications aim to interact with. Identifying and understanding these targets is essential for developing effective drugs. Examples include proteins like GPCRs that play roles in cell signaling.

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FDA

Food and Drug Administration

The FDA is a US government agency responsible for protecting public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological products, medical devices, our nation's food supply, cosmetics, and products that emit radiation.

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Cancer

Uncontrolled growth and spread of abnormal cells.

Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. These cells can invade surrounding tissues and spread to other parts of the body.

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Diabetes

A metabolic disorder affecting blood sugar regulation.

Diabetes is a chronic condition where the body either doesn't produce enough insulin or can't effectively use the insulin it produces. This leads to high blood sugar levels and can cause various complications.

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Depression

A mood disorder characterized by persistent sadness and loss of interest.

Depression is a common mental health disorder that involves persistent feelings of sadness, hopelessness, and loss of interest in activities. It can affect thoughts, behavior, sleep, appetite, and energy levels.

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Anxiety

Excessive worry and fear.

Anxiety is a feeling of unease, nervousness, or apprehension. It can be mild or severe, and it often involves physical symptoms like rapid heartbeat, sweating, and shortness of breath.