RESEARCH: CANCER
FOLDING PROJECT #12000 PROFILE

Class A GPCRs are important proteins that help regulate our bodies. They act like messengers, transmitting signals between the outside and inside of cells. This project relates to understanding how these proteins work so we can develop better drugs for diseases like cancer, diabetes, depression, and anxiety.

Note: This TLDR is a simplication and may not be 100% accurate.

Class A GPCRs: Class A GPCRs are pivotal drug targets in our body, as they are involved in regulating almost all homeostatic processes in the human body.

It is estimated that around 35% of all drugs currently approved by the FDA target one of these GPCRs.

These proteins act like 'molecular telephones' and transmit signals from outside the cell to inside the cell.

Here, we aim to study the process that underlies their action on our body.

This is integral for providing insights into the protein's function and design better and new drugs targeting cancer, diabetes, depression and anxiety.

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GPCR

G Protein-Coupled Receptor

GPCRs are a large family of cell surface receptors that bind to signaling molecules and activate intracellular pathways. They are involved in many physiological processes, including vision, smell, taste, and hormone regulation.

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Drug Targets

Molecules or pathways that are intended to be modulated by drugs to achieve a therapeutic effect.

Drug targets are the specific molecules or biological processes that drugs aim to influence. Identifying and targeting these molecules is crucial for developing new and effective therapies.

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FDA

Food and Drug Administration

The FDA is a US federal agency responsible for protecting public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological products, medical devices, our nation's food supply, cosmetics, and products that emit radiation.

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Cancer

A group of diseases characterized by uncontrolled cell growth and spread.

Cancer is a broad term for diseases where abnormal cells grow and divide uncontrollably. This can lead to tumors, which can invade surrounding tissues and spread to other parts of the body.

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Diabetes

A metabolic disorder characterized by high blood sugar levels.

Diabetes occurs when the body either doesn't produce enough insulin or can't effectively use the insulin it produces. Insulin is a hormone that regulates blood sugar levels.

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Depression

A mood disorder characterized by persistent sadness and loss of interest.

Depression is a common mental health condition that affects how you feel, think, and act. Symptoms can include feelings of sadness, hopelessness, fatigue, and changes in sleep and appetite.

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Anxiety

A feeling of worry, nervousness, or unease.

Anxiety is a common human emotion that everyone experiences from time to time. However, when anxiety becomes excessive and persistent, it can interfere with daily life.