RESEARCH: CANCER
FOLDING PROJECT #12008 PROFILE

This project relates to Class A GPCRs, which are like tiny 'molecular telephones' in our bodies that control important processes. About 35% of FDA-approved drugs work on these proteins! Studying how they function could lead to better treatments for diseases like cancer, diabetes, depression, and anxiety.

Note: This TLDR is a simplication and may not be 100% accurate.

Class A GPCRs: Class A GPCRs are pivotal drug targets in our body, as they are involved in regulating almost all homeostatic processes in the human body.

It is estimated that around 35% of all drugs currently approved by the FDA target one of these GPCRs.

These proteins act like 'molecular telephones' and transmit signals from outside the cell to inside the cell.

Here, we aim to study the process that underlies their action on our body.

This is integral for providing insights into the protein's function and design better and new drugs targeting cancer, diabetes, depression and anxiety.

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GPCR

G Protein-Coupled Receptor

GPCRs are a large family of cell surface receptors that play a crucial role in transmitting signals from outside the cell to the inside. They are involved in a wide range of physiological processes and are important targets for drug development.

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Drug Targets

Molecules or biological pathways that are targeted by drugs to achieve a therapeutic effect.

Drug targets are specific molecules or processes within the body that are aimed at by medications. Understanding these targets is essential for developing new and effective treatments for diseases.

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FDA

Food and Drug Administration

The FDA is a government agency responsible for ensuring the safety and efficacy of drugs, medical devices, and other healthcare products in the United States.

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Cancer

A disease characterized by the uncontrolled growth and spread of abnormal cells.

Cancer is a group of diseases involving abnormal cell growth that can spread to other parts of the body. It is a leading cause of death worldwide.

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Diabetes

A chronic metabolic disorder characterized by elevated blood sugar levels.

Diabetes is a condition where the body has trouble regulating blood sugar. It can lead to various complications if not managed properly.

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Depression

A mood disorder characterized by persistent sadness, loss of interest, and other symptoms.

Depression is a common mental health condition that affects people's thoughts, feelings, and behaviors. It can cause significant distress and impact daily life.

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Anxiety

A feeling of worry, nervousness, or unease.

Anxiety is a normal human emotion, but when it becomes excessive or persistent, it can be a sign of an anxiety disorder. Symptoms can include racing thoughts, restlessness, and physical tension.