RESEARCH: CANCER
FOLDING PROJECT #12006 PROFILE

This project relates to understanding how Class A GPCRs work. These proteins are like cellular phones, transmitting signals that control many bodily functions. Learning how they function could lead to better treatments for diseases like cancer, diabetes, depression, and anxiety.

Note: This TLDR is a simplication and may not be 100% accurate.

Class A GPCRs: Class A GPCRs are pivotal drug targets in our body, as they are involved in regulating almost all homeostatic processes in the human body.

It is estimated that around 35% of all drugs currently approved by the FDA target one of these GPCRs.

These proteins act like 'molecular telephones' and transmit signals from outside the cell to inside the cell.

Here, we aim to study the process that underlies their action on our body.

This is integral for providing insights into the protein's function and design better and new drugs targeting cancer, diabetes, depression and anxiety.

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GPCR

G protein-coupled receptor

GPCRs are a large family of proteins found on the surface of cells that receive signals from outside the cell and transmit them inside the cell. They play important roles in many physiological processes and are targets for many drugs.

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Drug Targets

Molecules or biological pathways that are intended to be affected by a drug in order to produce a therapeutic effect.

Drug targets are the specific molecules or pathways in the body that drugs aim to interact with. Understanding these targets is crucial for developing effective medications.

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FDA

Food and Drug Administration

The FDA is a US government agency responsible for regulating the safety and efficacy of food, drugs, medical devices, and other products.

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Cancer

A group of diseases characterized by uncontrolled cell growth and spread.

Cancer is a serious illness where cells in the body grow uncontrollably. It can affect various organs and tissues.

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Diabetes

A metabolic disorder characterized by high blood sugar levels.

Diabetes occurs when the body has trouble regulating blood sugar. It can lead to complications affecting various organs.

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Depression

A mood disorder characterized by persistent feelings of sadness, hopelessness, and loss of interest.

Depression is a common mental health condition that affects a person's thoughts, feelings, and behaviors. It can cause significant distress and impact daily life.

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Anxiety

A feeling of worry, nervousness, or unease.

Anxiety is a normal human emotion but can become excessive and interfere with daily functioning. It can manifest in various ways, including physical symptoms.