RESEARCH: CANCER
FOLDING PROJECT #12014 PROFILE

This project relates to Class A GPCRs, which are important proteins that control many bodily functions and are targeted by 35% of approved drugs. These 'molecular telephones' send signals within our cells, helping us understand how they work and create new treatments for diseases like cancer, diabetes, depression, and anxiety.

Note: This TLDR is a simplication and may not be 100% accurate.

Class A GPCRs: Class A GPCRs are pivotal drug targets in our body, as they are involved in regulating almost all homeostatic processes in the human body.

It is estimated that around 35% of all drugs currently approved by the FDA target one of these GPCRs.

These proteins act like 'molecular telephones' and transmit signals from outside the cell to inside the cell.

Here, we aim to study the process that underlies their action on our body.

This is integral for providing insights into the protein's function and design better and new drugs targeting cancer, diabetes, depression and anxiety.

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GPCR

G protein-coupled receptor

GPCRs are a large family of cell surface receptors that play a crucial role in transmitting signals from outside the cell to the inside. They are involved in various physiological processes and are targeted by many drugs.

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Drug Targets

Specific molecules or pathways that are intended to be affected by drugs.

Drug targets are the specific biological molecules, such as proteins or enzymes, that drugs aim to interact with and modulate. Identifying and understanding drug targets is essential for developing new therapies.

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FDA

Food and Drug Administration

The FDA is a US government agency responsible for protecting public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological products, medical devices, our nation's food supply, cosmetics, and products that emit radiation.

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Cancer

A group of diseases characterized by uncontrolled cell growth and spread.

Cancer is a group of diseases where abnormal cells divide uncontrollably and can invade other tissues. It arises from genetic mutations that disrupt normal cell growth and death.

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Diabetes

A metabolic disorder characterized by high blood sugar levels.

Diabetes is a chronic condition where the body either doesn't produce enough insulin or can't effectively use the insulin it produces. This leads to elevated blood sugar levels, affecting various organs and tissues.

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Depression

A mood disorder characterized by persistent feelings of sadness, hopelessness, and loss of interest.

Depression is a common mental health condition marked by prolonged feelings of sadness, emptiness, and loss of interest in activities. It can significantly impact daily life and well-being.

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Anxiety

A feeling of worry, nervousness, or unease.

Anxiety is a common human emotion characterized by feelings of worry, fear, and apprehension. It can manifest in various ways, from mild nervousness to debilitating panic attacks.