RESEARCH: CANCER
FOLDING PROJECT #12001 PROFILE

This project looks at Class A GPCRs, proteins that act like cell-signaling telephones. They control many body functions and are drug targets for diseases like cancer, diabetes, and mental health issues. Understanding how they work helps us design better medications.

Note: This TLDR is a simplication and may not be 100% accurate.

Class A GPCRs: Class A GPCRs are pivotal drug targets in our body, as they are involved in regulating almost all homeostatic processes in the human body.

It is estimated that around 35% of all drugs currently approved by the FDA target one of these GPCRs.

These proteins act like 'molecular telephones' and transmit signals from outside the cell to inside the cell.

Here, we aim to study the process that underlies their action on our body.

This is integral for providing insights into the protein's function and design better and new drugs targeting cancer, diabetes, depression and anxiety.

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GPCR

G protein-coupled receptor

GPCRs are a large family of cell surface receptors that play a crucial role in transmitting signals within the body. They are involved in a wide range of physiological processes, including sensory perception, hormone regulation, and immune responses.

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Drug Targets

Molecules or biological pathways that are the intended sites of action for pharmaceutical drugs.

Drug targets are specific molecules or pathways within the body that are thought to be involved in disease processes. By targeting these molecules, drugs can aim to modulate their activity and treat the underlying condition.

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FDA

Food and Drug Administration

The FDA is a federal agency responsible for protecting public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological products, medical devices, our nation's food supply, cosmetics, and products that emit radiation.

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Cancer

A disease characterized by uncontrolled cell growth and spread.

Cancer is a group of diseases that involve abnormal cell growth and the ability to invade or spread to other parts of the body. There are many different types of cancer, each with its own characteristics and treatments.

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Diabetes

A metabolic disorder characterized by high blood sugar levels.

Diabetes is a chronic condition that affects how the body regulates blood sugar. There are two main types: type 1 diabetes, where the body doesn't produce insulin, and type 2 diabetes, where the body doesn't use insulin properly.

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Depression

A mood disorder characterized by persistent feelings of sadness and loss of interest.

Depression is a common mental health condition that can affect people of all ages. It involves a persistent feeling of sadness, hopelessness, and loss of interest in activities once enjoyed.

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Anxiety

A feeling of worry, nervousness, or unease.

Anxiety is a normal human emotion that can be triggered by stressful situations. However, when anxiety becomes excessive and persistent, it can interfere with daily life.