RESEARCH: CANCER
FOLDING PROJECT #12004 PROFILE

Class A GPCR proteins are super important for our bodies, controlling almost everything! 💊 They act like cell phones, sending signals inside and out. This project looks at how they work so we can make better drugs for diseases like cancer, diabetes, and depression.

Class A GPCRs: Class A GPCRs are pivotal drug targets in our body, as they are involved in regulating almost all homeostatic processes in the human body.

It is estimated that around 35% of all drugs currently approved by the FDA target one of these GPCRs.

These proteins act like 'molecular telephones' and transmit signals from outside the cell to inside the cell.

Here, we aim to study the process that underlies their action on our body.

This is integral for providing insights into the protein's function and design better and new drugs targeting cancer, diabetes, depression and anxiety.

GPCRs

G Protein-Coupled Receptors

GPCRs are a large family of proteins found on the surface of cells. They bind to signaling molecules and trigger changes inside the cell. GPCRs are important for many bodily functions, and they are targets for many drugs.

FDA

Food and Drug Administration

The FDA is a government agency responsible for protecting public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological products, medical devices, our nation's food supply, cosmetics, and products that emit radiation.

Cancer

A group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

Cancer is a disease caused by uncontrolled cell growth. It can affect any part of the body and can spread to other tissues and organs.

Diabetes

A metabolic disorder characterized by high blood sugar levels due to problems with insulin production or action.

Diabetes is a condition where the body has trouble regulating blood sugar. This can happen because the body doesn't make enough insulin, or because the body doesn't use insulin properly.

Depression

A mood disorder characterized by persistent feelings of sadness, hopelessness, and loss of interest in activities.

Depression is a common mental health disorder that can cause feelings of sadness, hopelessness, and loss of energy. It can affect people of all ages and backgrounds.

Anxiety

A feeling of worry, nervousness, or unease, typically about an imminent event or something with an uncertain outcome.

Anxiety is a normal human emotion, but when it becomes excessive and interferes with daily life, it can be a sign of an anxiety disorder.