RESEARCH: CANCER
FOLDING PROJECT #12012 PROFILE

This project studies Class A GPCRs, proteins that act like 'molecular telephones' and control many body functions. Understanding how they work can help develop new drugs for diseases like cancer, diabetes, and depression.

Class A GPCRs: Class A GPCRs are pivotal drug targets in our body, as they are involved in regulating almost all homeostatic processes in the human body.

It is estimated that around 35% of all drugs currently approved by the FDA target one of these GPCRs.

These proteins act like 'molecular telephones' and transmit signals from outside the cell to inside the cell.

Here, we aim to study the process that underlies their action on our body.

This is integral for providing insights into the protein's function and design better and new drugs targeting cancer, diabetes, depression and anxiety.

GPCRs

G protein-coupled receptors

GPCRs are a large family of cell surface receptors that play a vital role in transmitting signals from outside the cell to the inside. They are involved in many physiological processes and are important drug targets for various diseases.

FDA

Food and Drug Administration

The FDA is a federal agency responsible for protecting public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological products, medical devices, our nation's food supply, cosmetics, and products that emit radiation.

Cancer

Uncontrolled growth of abnormal cells

Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. It can affect any part of the body and can be caused by genetic mutations, environmental factors, or a combination of both.

Diabetes

A metabolic disorder characterized by high blood sugar levels

Diabetes is a chronic condition that affects how your body regulates blood sugar. It occurs when the pancreas does not produce enough insulin or when the body becomes resistant to insulin. This can lead to various complications, including heart disease, stroke, and nerve damage.

Depression

A mood disorder characterized by persistent sadness and loss of interest

Depression is a common mental health disorder that can significantly impact a person's thoughts, feelings, and behaviors. It involves persistent feelings of sadness, hopelessness, and loss of interest in activities that were once enjoyable.

Anxiety

A feeling of worry, nervousness, or unease

Anxiety is a normal human emotion that everyone experiences from time to time. However, when it becomes excessive and persistent, it can interfere with daily life. It can manifest as physical symptoms like rapid heartbeat, sweating, and difficulty breathing, as well as emotional distress.