RESEARCH: DIABETES
FOLDING PROJECT #14951 PROFILE

This project studies how certain proteins on cell surfaces change shape when activated. These proteins are linked to diseases like diabetes and high blood pressure. Understanding their movements can help scientists design new and better drugs to treat these conditions.

Class B G-Protein Coupled Receptors: Class B G-Protein coupled receptors (GPCRs) are membrane proteins involved in the pathogenesis of diabetes, high blood pressure, osteoporosis, etc.

Here, we are trying to study the conformational dynamics of the Glucagon Receptor, Glucagon-like Peptide 1 receptor, PArathyroid Hormone Receptor, Pituitary Adenlyate Cyclase Receptor and Secretin Receptor - All Class B GPCRs.

These studies will help in designing better drugs that target these receptors.

Class B G-Protein Coupled Receptors

Membrane proteins involved in various physiological processes.

Class B G-Protein Coupled Receptors (GPCRs) are a group of membrane proteins that play crucial roles in transmitting signals within cells. They are involved in a wide range of physiological processes, including hormone regulation, metabolism, and immune responses. These receptors bind to specific ligands, such as hormones or neurotransmitters, which triggers a cascade of events inside the cell, ultimately leading to a biological response.

GPCRs

G-Protein Coupled Receptors

GPCRs are a large family of cell surface receptors that play a vital role in signal transduction. They bind to various ligands, including hormones, neurotransmitters, and light, and activate intracellular signaling pathways.

Glucagon Receptor

Receptor for the hormone glucagon.

The Glucagon Receptor is a cell surface protein that binds to the hormone glucagon. When glucagon binds to its receptor, it triggers signaling pathways that increase blood glucose levels by stimulating the liver to release stored glucose.

Glucagon-like Peptide 1 Receptor

Receptor for the hormone GLP-1.

The Glucagon-like Peptide 1 Receptor (GLP-1R) is a cell surface protein that binds to the hormone GLP-1. Activation of GLP-1R promotes insulin secretion, suppresses glucagon release, and slows gastric emptying, contributing to blood glucose control.

PArathyroid Hormone Receptor

Receptor for the hormone parathyroid hormone.

The Parathyroid Hormone Receptor (PTH1R) is a cell surface protein that binds to parathyroid hormone. Activation of PTH1R increases blood calcium levels by stimulating bone resorption and promoting calcium reabsorption in the kidneys.

Secretin Receptor

Receptor for the hormone secretin.

The Secretin Receptor is a cell surface protein that binds to the hormone secretin. Activation of secretin receptor stimulates pancreatic bicarbonate secretion, which neutralizes acidic chyme entering the duodenum.