RESEARCH: DIABETES
FOLDING PROJECT #14950 PROFILE

This project studies how Class B G-protein coupled receptors (important for things like blood sugar and bone health) change shape. Understanding these changes can help scientists design better drugs to treat conditions like diabetes and osteoporosis.

Note: This TLDR is a simplication and may not be 100% accurate.

Class B G-Protein Coupled Receptors: Class B G-Protein coupled receptors (GPCRs) are membrane proteins involved in the pathogenesis of diabetes, high blood pressure, osteoporosis, etc.

Here, we are trying to study the conformational dynamics of the Glucagon Receptor, Glucagon-like Peptide 1 receptor, PArathyroid Hormone Receptor, Pituitary Adenlyate Cyclase Receptor and Secretin Receptor - All Class B GPCRs.

These studies will help in designing better drugs that target these receptors.

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Class B G-Protein Coupled Receptors

Membrane proteins involved in various diseases.

Class B G-Protein Coupled Receptors are a type of membrane protein that plays a role in many biological processes. They are important targets for drug development because they are involved in diseases like diabetes, high blood pressure, and osteoporosis.

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GPCRs

G-Protein Coupled Receptors

GPCRs are a large family of cell surface receptors that play a crucial role in transmitting signals from outside the cell to inside. They are involved in various physiological processes and are targets for many drugs.

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Glucagon Receptor

A receptor that binds to glucagon.

The Glucagon Receptor is a protein found on the surface of cells. It binds to the hormone glucagon, which helps regulate blood sugar levels.

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Glucagon-like Peptide 1 receptor

A receptor that binds to glucagon-like peptide 1.

The Glucagon-like Peptide 1 receptor is a protein found on the surface of cells. It binds to the hormone glucagon-like peptide 1, which helps regulate blood sugar levels and promotes insulin release.

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PArathyroid Hormone Receptor

A receptor that binds to parathyroid hormone.

The Parathyroid Hormone Receptor is a protein found on the surface of cells. It binds to the hormone parathyroid hormone, which helps regulate calcium levels in the blood.

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Pituitary Adenylate Cyclase Receptor

A receptor that activates adenylate cyclase.

The Pituitary Adenylate Cyclase Receptor is a protein found on the surface of cells. It binds to hormones like gonadotropin-releasing hormone (GnRH) and stimulates the production of cyclic AMP, which plays a role in various cellular processes.

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Secretin Receptor

A receptor that binds to the hormone secretin.

The Secretin Receptor is a protein found on the surface of cells. It binds to the hormone secretin, which stimulates the pancreas to release bicarbonate, helping regulate digestion.