RESEARCH: DIABETES
FOLDING PROJECT #14923 PROFILE

This project studies how certain cell receptors change shape when activated. These receptors are involved in diseases like diabetes and high blood pressure. Understanding these changes can help create better medications that target these receptors.

G-Protein Coupled Receptors: G-Protein coupled receptors (GPCRs) are membrane proteins involved in the pathogenesis of diabetes, high blood pressure, osteoporosis, etc.

Here, we are trying to study the conformational dynamics of the Glucagon Receptor, Glucagon-like Peptide 1 receptor, PArathyroid Hormone Receptor, Pituitary Adenlyate Cyclase Receptor and Secretin Receptor - All Class B GPCRs.

These studies will help in designing better drugs that target these receptors.

G-Protein Coupled Receptors

GPCRs

G-Protein Coupled Receptors (GPCRs) are a large family of cell surface receptors involved in transmitting signals within cells. They play a crucial role in various physiological processes, including hormone response, neurotransmission, and immune function.

Glucagon Receptor

A receptor protein that binds to glucagon, a hormone involved in regulating blood sugar levels.

The Glucagon Receptor is a type of cell surface receptor that responds to the hormone glucagon. When glucagon binds to this receptor, it triggers a series of events inside the cell that ultimately lead to an increase in blood glucose levels.

Glucagon-like Peptide 1 receptor

GLP-1R

The Glucagon-like Peptide 1 receptor (GLP-1R) is a type of cell surface receptor that responds to the hormone glucagon-like peptide 1 (GLP-1). GLP-1 plays a role in regulating blood sugar levels and appetite.

Parathyroid Hormone Receptor

A receptor protein that binds to parathyroid hormone (PTH), a hormone involved in regulating calcium levels.

The Parathyroid Hormone Receptor is a cell surface receptor that responds to the hormone parathyroid hormone (PTH). PTH plays a crucial role in maintaining calcium balance in the body.

Pituitary Adenylate Cyclase Activating Polypeptide

PACAP is a neuropeptide involved in various physiological processes.

Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) is a signaling molecule that plays a role in diverse bodily functions, including hormone regulation, neurotransmission, and immune responses.

Secretin Receptor

A receptor protein that binds to secretin, a hormone involved in regulating digestive processes.

The Secretin Receptor is a cell surface receptor that responds to the hormone secretin. Secretin plays a key role in stimulating pancreatic bicarbonate secretion and regulating gastric acid production.