RESEARCH: DIABETES
FOLDING PROJECT #14921 PROFILE

This project studies how certain receptors in the body change shape when activated by hormones. These receptors are linked to diseases like diabetes and high blood pressure. Understanding how they work can help scientists design better drugs to treat these conditions.

G-Protein Coupled Receptors: G-Protein coupled receptors (GPCRs) are membrane proteins involved in the pathogenesis of diabetes, high blood pressure, osteoporosis, etc.

Here, we are trying to study the conformational dynamics of the Glucagon Receptor, Glucagon-like Peptide 1 receptor, PArathyroid Hormone Receptor, Pituitary Adenlyate Cyclase Receptor and Secretin Receptor - All Class B GPCRs.

These studies will help in designing better drugs that target these receptors.

G-Protein Coupled Receptors

GPCRs

G-Protein Coupled Receptors are a large family of cell surface proteins that play a crucial role in transmitting signals within the body. They are involved in a wide range of physiological processes, including hormone regulation, neurotransmission, and immune response.

Glucagon Receptor

A type of G-protein coupled receptor that binds to the hormone glucagon.

The Glucagon Receptor is a protein found on the surface of cells in the liver and other tissues. It plays a vital role in regulating blood sugar levels by responding to the hormone glucagon. When glucagon binds to its receptor, it triggers a cascade of events that lead to the release of glucose from the liver into the bloodstream.

Glucagon-like Peptide 1 Receptor

GLP-1R

The Glucagon-like Peptide 1 Receptor (GLP-1R) is a protein found on the surface of cells in the pancreas and other tissues. It plays a crucial role in regulating blood sugar levels by responding to the hormone GLP-1. When GLP-1 binds to its receptor, it stimulates the release of insulin from the pancreas.

PArathyroid Hormone Receptor

PTH1R

The Parathyroid Hormone Receptor (PTH1R) is a protein found on the surface of various cells in the body. It plays a crucial role in regulating calcium levels by responding to the hormone parathyroid hormone (PTH). When PTH binds to its receptor, it stimulates bone breakdown and calcium release into the bloodstream.

Pituitary Adenylate Cyclase Receptor

PACR

The Pituitary Adenylate Cyclase Receptor (PACR) is a protein found on the surface of pituitary cells. It plays a crucial role in hormone regulation by responding to various hormones released from the hypothalamus. When these hormones bind to PACR, it triggers a cascade of events that lead to the production and release of other hormones.

Secretin Receptor

A type of G-protein coupled receptor that binds to the hormone secretin.

The Secretin Receptor is a protein found on the surface of cells in the pancreas and other tissues. It plays a crucial role in regulating digestion by responding to the hormone secretin. When secretin binds to its receptor, it stimulates the release of bicarbonate from the pancreas into the small intestine, which helps neutralize acidic chyme.