RESEARCH: DIABETES
FOLDING PROJECT #14945 PROFILE

This project relates to studying how special proteins on our cells change shape when they're triggered by hormones like glucagon and parathyroid hormone. Understanding these changes can help us create better medications for diseases like diabetes, high blood pressure, and osteoporosis.

G-Protein Coupled Receptors: G-Protein coupled receptors (GPCRs) are membrane proteins involved in the pathogenesis of diabetes, high blood pressure, osteoporosis, etc.

Here, we are trying to study the conformational dynamics of the Glucagon Receptor, Glucagon-like Peptide 1 receptor, PArathyroid Hormone Receptor, Pituitary Adenlyate Cyclase Receptor and Secretin Receptor - All Class B GPCRs.

These studies will help in designing better drugs that target these receptors.

G-Protein Coupled Receptors

G protein-coupled receptors (GPCRs)

G-Protein Coupled Receptors are a large family of proteins found on the surface of cells that bind to signaling molecules. They play a crucial role in transmitting signals within the body, influencing various processes like hormone regulation, sensory perception, and immune responses.

Glucagon Receptor

A type of G protein-coupled receptor that binds to glucagon.

The Glucagon Receptor is a protein found on the surface of liver cells. It binds to the hormone glucagon, triggering processes that release glucose into the bloodstream.

Glucagon-like Peptide 1 receptor

GLP-1 Receptor

The Glucagon-like Peptide 1 receptor is a protein that binds to the hormone GLP-1. It plays a role in regulating blood sugar levels and stimulating insulin release.

PArathyroid Hormone Receptor

Parathyroid Hormone 1 Receptor (PTH1R)

The Parathyroid Hormone Receptor is a protein found on various cells in the body. It binds to parathyroid hormone, which regulates calcium levels in the blood.

Pituitary Adenlyate Cyclase Receptor

Adenylate Cyclase-Coupled Receptors (ACRs)

Pituitary Adenylate Cyclase Receptors are proteins that play a role in regulating hormone release from the pituitary gland. They bind to various hormones and activate signaling pathways that control cellular processes.

Secretin Receptor

A type of G protein-coupled receptor that binds to the hormone secretin.

The Secretin Receptor is a protein found on cells in the pancreas and intestine. It binds to the hormone secretin, triggering the release of bicarbonate from the pancreas, which neutralizes stomach acid in the duodenum.