RESEARCH: DIABETES
FOLDING PROJECT #14914 PROFILE

This project looks at how certain cell receptors change shape when activated. These receptors are linked to diseases like diabetes and high blood pressure. Understanding how they work will help scientists design better medicines to treat these conditions.

Note: This TLDR is a simplication and may not be 100% accurate.

G-Protein Coupled Receptors: G-Protein coupled receptors (GPCRs) are membrane proteins involved in the pathogenesis of diabetes, high blood proessure, skin cancer, osteoporosis, etc.

Here, we are trying to studying the conformational dynamics of Glucagon Receptor, Glucagon-like Peptide 1 receptor, PArathyroid Hormone Receptor, Pituitary Adenlyate Cyclase Receptor and Secretin Receptor - All Class B GPCRs.

These studies will help in designing better drugs that target these receptors.

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G-Protein Coupled Receptors

GPCRs

G-Protein Coupled Receptors (GPCRs) are a large family of cell surface receptors involved in transmitting signals within cells. They play crucial roles in various physiological processes and are targets for numerous drugs.

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Diabetes

A chronic metabolic disorder characterized by high blood sugar levels.

Diabetes is a condition where the body either doesn't produce enough insulin or can't effectively use the insulin it produces. Insulin is a hormone that regulates blood sugar levels. This leads to elevated blood sugar, which can damage various organs over time.

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High Blood Pressure

Elevated blood pressure

High blood pressure, also known as hypertension, is a condition where the force of blood against your artery walls is consistently too high. Over time, it can damage your heart, blood vessels, and other organs.

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Skin Cancer

Cancer that originates in the skin.

Skin cancer is a disease characterized by the uncontrolled growth of abnormal cells in the skin. It is often caused by prolonged exposure to ultraviolet (UV) radiation from the sun or tanning beds.

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Osteoporosis

A condition characterized by weak and brittle bones.

Osteoporosis is a bone disease that occurs when the body loses too much bone, makes too little bone, or both. This can lead to fragile bones that are more likely to fracture.

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Glucagon Receptor

A type of G-protein coupled receptor that binds to glucagon.

The Glucagon Receptor is a cell surface receptor that responds to the hormone glucagon. Glucagon plays a vital role in regulating blood sugar levels by stimulating the liver to release stored glucose.

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Glucagon-like Peptide 1 Receptor

A type of G-protein coupled receptor that binds to glucagon-like peptide 1 (GLP-1).

The Glucagon-like Peptide 1 Receptor (GLP-1R) is a cell surface receptor involved in regulating blood sugar levels. It is activated by the hormone GLP-1, which stimulates insulin release from the pancreas.

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Parathyroid Hormone Receptor

A type of G-protein coupled receptor that binds to parathyroid hormone.

The Parathyroid Hormone Receptor (PTHr) is a cell surface receptor that plays a crucial role in regulating calcium and phosphate levels in the body. It responds to the hormone parathyroid hormone (PTH).

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Pituitary Adenylate Cyclase Activating Polypeptide

A polypeptide hormone that activates adenylate cyclase.

Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) is a neuropeptide hormone involved in various physiological processes, including regulating stress response, neurotransmission, and growth. It acts by binding to specific receptors and activating adenylate cyclase.

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Secretin Receptor

A type of G-protein coupled receptor that binds to the hormone secretin.

The Secretin Receptor is a cell surface receptor that responds to the hormone secretin. Secretin plays a role in regulating pancreatic enzyme secretion and bicarbonate production.