RESEARCH: DIABETES
FOLDING PROJECT #14931 PROFILE

This project looks at how certain proteins in our bodies change shape. These proteins are involved in health problems like diabetes and high blood pressure. By understanding how they work, scientists hope to create better drugs to treat these conditions.

G-Protein Coupled Receptors: G-Protein coupled receptors (GPCRs) are membrane proteins involved in the pathogenesis of diabetes, high blood pressure, osteoporosis, etc.

Here, we are trying to study the conformational dynamics of the Glucagon Receptor, Glucagon-like Peptide 1 receptor, PArathyroid Hormone Receptor, Pituitary Adenlyate Cyclase Receptor and Secretin Receptor - All Class B GPCRs.

These studies will help in designing better drugs that target these receptors.

G-Protein Coupled Receptors

G protein-coupled receptors (GPCRs)

G Protein Coupled Receptors are a large family of cell surface proteins that play a crucial role in transmitting signals within the body. They respond to various stimuli like hormones, neurotransmitters, and light, initiating a cascade of events that ultimately regulate diverse cellular functions. GPCRs are implicated in numerous physiological processes, making them attractive targets for drug development.

Glucagon Receptor

A receptor that binds to the hormone glucagon

The Glucagon Receptor is a protein found on the surface of liver cells. It binds to the hormone glucagon, which triggers the release of glucose from the liver into the bloodstream. This process helps regulate blood sugar levels. Drugs targeting this receptor are used to treat diabetes.

Glucagon-like Peptide 1 Receptor

GLP-1 receptor

The Glucagon-like Peptide 1 Receptor (GLP-1R) is a protein found on the surface of cells in the pancreas and other tissues. It binds to the hormone GLP-1, which stimulates insulin release and suppresses glucagon secretion. Drugs that activate this receptor are used to treat type 2 diabetes.

PArathyroid Hormone Receptor

Parathyroid hormone receptor (PTH receptor)

The Parathyroid Hormone Receptor (PTH receptor) is a protein found on the surface of bone cells and other tissues. It binds to the hormone parathyroid hormone (PTH), which regulates calcium levels in the body. Drugs targeting this receptor are used to treat osteoporosis.

Pituitary Adenylate Cyclase Receptor

PAC1 receptor

The Pituitary Adenylate Cyclase Receptor (PAC1 receptor) is a protein found on the surface of pituitary cells. It binds to various hormones, including gonadotropin-releasing hormone (GnRH), which stimulates the release of other hormones. Drugs targeting this receptor are used in treating certain hormonal disorders.

Secretin Receptor

A receptor that binds to the hormone secretin

The Secretin Receptor is a protein found on the surface of cells in the pancreas and intestines. It binds to the hormone secretin, which stimulates bicarbonate secretion from the pancreas. This process helps neutralize stomach acid entering the small intestine. Drugs targeting this receptor are used to treat certain gastrointestinal disorders.